Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes

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Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes.

CC chemokine ligand 18 (CCL18) was originally discovered as pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1), and macrophage inflammatory protein-4 (MIP-4). CCL18 primarily targets lymphocytes and immature DC, although its agonistic receptor remains unknown so far. CCL18 is mainly ...

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CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.

ANCA-associated vasculitis is the most frequent cause of crescentic GN. To define new molecular and/or cellular biomarkers of this disease in the kidney, we performed microarray analyses of renal biopsy samples from patients with ANCA-associated crescentic GN. Expression profiles were correlated with clinical data in a prospective study of patients with renal ANCA disease. CC chemokine ligand 1...

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CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.

BACKGROUND Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. METHODS AND RESULTS Plasma samples of 54 patients with Braunwald class IIIB UAP were examined at baseline for 11 ...

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Coming of Age--CC Chemokine Ligand 18 in ANCA-Associated Vasculitis.

The management of pauci–immune focal necrotizing GN (FNGN) remains a challenge, with morbidity and mortality remaining stubbornly high. Well powered controlled clinical trials have optimized older treatments and introduced new ones, but substantial numbers of those affected still die of active disease or from the toxicity of the drugs used to treat it.1,2 Current strategies for tailoring therap...

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CC-chemokine ligand 18 is a useful biomarker associated with disease activity in IgG4-related disease.

IgG4-RD, IgG4-related disease; IL-2, interleukin-2. Figure 1 Serum CC-chemokine ligand 18 (CCL18) levels were elevated and correlated with disease activity in IgG4-RD. Serum CCL18 levels (A); correlation between serum CCL18 levels and disease activity (B) and allergic condition (C); correlation between serum CCL18 levels and atopic history (D); and longitudinal analysis of serum CCL18 levels af...

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ژورنال

عنوان ژورنال: Journal of Leukocyte Biology

سال: 2005

ISSN: 0741-5400

DOI: 10.1189/jlb.1204712